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Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Stopping the medication too early may allow bacteria to continue to grow resulting in a relapse of the infection. Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Although side effects from Cephalexin are not common, they can occur. This medication is a cephalosporin antibiotic used to treat a wide variety of bacterial infections. Medications with known interactions with Keflex include blood thinners, probenecid, and Metformin. Keflex is a semi-synthetic cephalosporin antibiotic for oral administration.